Squaramides

Squaramides are versatile hydrogen-bond donor catalysts widely applied in synthetic organic chemistry. Their strong binding ability and tunable structure make them valuable in asymmetric catalysis, anion recognition, and organocatalytic transformations. They are used to promote reactions such as Michael additions, Mannich reactions, and cyclizations with high selectivity. Beyond catalysis, squaramides also find applications in supramolecular chemistry and drug design, where they enhance molecular recognition and stability.